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Hi Dave, Thanks for reaching out for support with this issue. We haven’t had any issue reported with the specific lot you have, but on rare instances we do see similar feedback from customers. Could we hop on a call to review this? I am hoping to clarify some of the details, share some insights from our end, and craft a plan to get you blood that meets your needs. You can book a time that fits your schedule here: https://calendly.com/ahartmann-utak/30min Thank you, Andrew Hartmann Business Development Manager – 25020 Avenue Tibbitts Valencia, CA 91355 – D +1.661.567.0667 P +1.888.UTAK.LAB F +1.661.294.9272 – Book a Meeting with Me https://calendly.com/ahartmann-utak/30min utak.com From: Verbrugge, David A (DOH) <david.verbrugge@alaska.gov> Sent: Friday, November 14, 2025 4:16 PM To: Andrew Hartmann <ahartmann@utak.com> Subject: RE: UTAK Labs check in Thanks for the quote Andrew. Will get that placed shortly. On a separate product, we’re have a LC-MS/MS matrix issue on our THC panel. We’re using this product as our calibrator matrix. 44600-WB(F) Blank Whole Blood - Frozen We are doing matched deuterated internal standard (ISTD) calibration. The problem is the ISTD compound has a suppressed response in the blood matrix relative to the unlabeled THC. This leads to an apparent ISTD recovery of ~ 200% is real samples – which causes the reported THC concentration to ½ of the true value. I’ve never seen a situation like this – ISTD behaving significantly differently than the unlabeled drug. Our method cleanup is pretty extensive (protein crash and tuned Solid Phase Extraction). The issue is intermittent. We tried keeping the blood frozen until analysis. We tried spinning the blood prior to spiking. Some batches work just fine, but then a batch extraction will fail without obvious cause. Has anyone reported unusual matrix behavior? Thanks, Dave V. ~~~~~~~~~~~~~~~~~~~~~~~ Manager Analytical Toxicology State of Alaska | Department of Health & Social Services Division of Public Health | State of Alaska Public Health Lab 5455 Dr. Martin Luther King Jr Ave | Anchorage, AK 99507 Desk: 907-334-2156 | Cell: 907-351-1354 e-mail: David.Verbrugge@Alaska.gov