Activity

Shuijie Shen - November 24 VIEW RECORDING - 12 mins (No highlights): https://fathom.video/share/3aZpzA7sLSqSpBg6t4PwzV1YeHWfspri --- 0:00 - CJ (Nona Scientific) Let me connect to my earphone. Hi, Andrew. Howdy. Yeah, I cannot hear you here. Testing, testing. Let me connect to my phone. Can you hear me now? Thank you. Hi, can you hear me now? 0:34 - Andrew Hartmann (UTAK Laboratories) Yeah, yeah. 0:35 - CJ (Nona Scientific) I can hear you. Can you hear me? Yes. 0:39 - Andrew Hartmann (UTAK Laboratories) Oh, that's good. 0:40 - CJ (Nona Scientific) Do you go by CJ? 0:42 - Andrew Hartmann (UTAK Laboratories) Huh? 0:43 - CJ (Nona Scientific) Do you go by CJ? 0:45 - Andrew Hartmann (UTAK Laboratories) Yes. Yeah, I'm to CJ, yeah. Great to meet you. So we have an oral confirmation test. 0:57 - CJ (Nona Scientific) I need the... But it is discontinued if UTAK is discontinued, so we need to formulate a customer QC. Perfect. How can I do it? 1:14 - Andrew Hartmann (UTAK Laboratories) So going to a custom route, let me go ahead and share screen. Can I hear you? Oh, can you hear me now? I cannot hear you. What happened? 1:26 - CJ (Nona Scientific) Hello, hello? 1:31 - Andrew Hartmann (UTAK Laboratories) Can you hear me now? Oh, yes. Yes. I did. 1:35 - CJ (Nona Scientific) Yeah. Sometimes Teams disconnects from the headset. 1:39 - Andrew Hartmann (UTAK Laboratories) Sorry about that. If it's easier to switch to a phone call, we can do that. 1:46 - CJ (Nona Scientific) Yeah, that's good. I can hear you. Very good. 1:51 - Andrew Hartmann (UTAK Laboratories) Perfect. So this was kind of the design of the stock product you had been purchasing from us. Yeah. Since we're going to be Making this as a custom product for you, you can change anything that you want. We can change how much material is in each vial. You can add or remove analytes. You can change any concentrations. So you've got a lot of flexibility now moving to a custom control. Yeah. So kind of my first questions are, you know, how much material are you using of this in, say, a week? How much material? 2:30 - CJ (Nona Scientific) I calculated about 25 microliters per year if we didn't increase the frequency of the test. We only test twice a week. So it's only, we cost 25 microliters per year. Okay. 2:49 - Andrew Hartmann (UTAK Laboratories) And then the actual fill size per vial. Do you like that 3ml fill size? Would you want to change that to like a 1ml? What's ideal for you? One ml is good. 3:04 - CJ (Nona Scientific) It's that ideal. 3:07 - Andrew Hartmann (UTAK Laboratories) So our minimum order size to make a custom control is 50 ml. So we'll have to quote you for 50 ml, but we'll do 50 of those 1 ml vials. So they'll be, you know, kind of easier for you to use that way. Yes. 3:25 - CJ (Nona Scientific) And then, can you, so if the stability is enough for about, what's the stability of the? So with the oral fluid, it's a one year stability. 3:40 - Andrew Hartmann (UTAK Laboratories) So we're going to be making it just for you. So it's going to be a brand new product when you get it. So you'll get the full year, but it is just a one year. So, you know, with you only using 25 ml per year, unfortunately, it will be, you know, more than what you're going to use in the shelf life. 4:02 - CJ (Nona Scientific) Can you lyophilize the product, the QC? We do not lyophilize the oral fluid. 4:10 - Andrew Hartmann (UTAK Laboratories) It does not perform. Oh, okay. It didn't work. So are you able to see my screen where you can see the list of analytes? Yes, I can see it. Is there any of these that you are not testing for? We don't test. 4:28 - CJ (Nona Scientific) We don't test the data. Oratory. I don't which one? 4:32 - Andrew Hartmann (UTAK Laboratories) barbitor it, the secubarbiter. 4:37 - CJ (Nona Scientific) Yes, this one. I don't need it. And I don't want the PCT and Prococophone. I want more the other stuff. So I will submit a sheet for the parameter list for the components of the PC. Okay. 4:57 - Andrew Hartmann (UTAK Laboratories) Yeah, that would be even better. if you can send me a list of specifically which analytes you want in, and then also what you want for the concentrations. So since we're making this just for you, we can keep the same concentrations, or you can pick any concentrations you want. And then are there any drugs not in this that you wish were present? 5:26 - CJ (Nona Scientific) It's not in this, yeah. Some of them is not in this, yeah. Now would be your opportunity to add those as well. 5:34 - Andrew Hartmann (UTAK Laboratories) So when you send me your drug list, don't just remove what you're not testing for. Tell us what you would want us to add in as well. That way we can make it the best value for you. 5:45 - CJ (Nona Scientific) Yeah, I'll send you a full list of the components, analytes, and the concentration. Perfect. Yeah, need the list of the analytes. 5:54 - Andrew Hartmann (UTAK Laboratories) I also need your target concentrations. So with those two pieces, that... That'll be enough information for me to get a price quote worked up. So we'll quote you a one mil fill size. We'll do 50 vials because that's our minimum order size. And then I'll wait for you to send me an email with the list of all of the drugs you want in and your target concentrations. Okay. Okay. 6:20 - CJ (Nona Scientific) So I need to order 50 milliliters. That is our minimum order size to make it. 6:27 - Andrew Hartmann (UTAK Laboratories) We have to make that much material just to be able to ensure our accuracy? Yeah. 6:33 - CJ (Nona Scientific) I once ordered the customer QC with 16 compounds. And the concentration is up. Most of them is two nanograms per milliliter. So it'll give me approximately, right? Not accurate, just approximately. Actually. I can't give an estimate because it all depends on the drugs. 6:59 - Andrew Hartmann (UTAK Laboratories) Some drugs. They're very cheap. Other drugs are very expensive. So until we have that final list, but it'll take our team, once you get me that list, about two or three days, and I'll have a price quote for you. And then once I have that quote ready, I'll send you out a link so we can connect again on a call like this, and we'll just go through the quote together and answer any questions, decide if we want to make any other changes, and kind of finalize a design from there. 7:25 - CJ (Nona Scientific) Okay, you cannot lifelike the oral fluid. We do not do that, no. And you lifelike the sample in the water, then I add the, I constitute the lifelike with the oral fluid. Is it possible? I don't believe we can do that. 7:50 - Andrew Hartmann (UTAK Laboratories) I think the better alternative, if we were going to be approaching it that way, would be to do it in methanol. So we can make like a stock solution. Where we put all of the drugs in methanol, and then you can use that to then, you know, dilute down into the blank oral fluid, you know, potentially even to make a multi-level QC or multi-level calibrator. I think, you know, if we're just diluting it in water and then trying to lyophilize that, I don't see stability really working out in that because all of that water is going to disappear and you're just going to end up with, like, some drug residue clung to the side of the vial. But a methanol stock mixture, we do see a lot of our customers do, where we, you know, you take a higher level concentration of it in the methanol, and then you're able to squirt the methanol into our blank oral fluid. 8:44 - CJ (Nona Scientific) Ah, well, yes. So, if I ask you to make the methanol, the methanol stability, the question is true, right? 9:04 - Andrew Hartmann (UTAK Laboratories) So, generally speaking, the stability in methanol is going to be much greater than the stability in oral fluid. The challenge that we're going to have is we don't have stability data on the analytes in methanol, so we aren't able to make a stability claim like we are with it in oral fluid or urine. I can tell you in practice, I've been doing this for 10 years at UTAK, it will have better stability in methanol, but I just can't tell you that on paper, unfortunately, because, like, in order to generate stability, we have to go through all of these stability studies and accelerate it in real time, multiple lots in the matrices. So, for oral fluid, for urine, you know, we make those products so often, we have that stability data, but in methanol, we just don't have that same data to make a claim. 9:58 - CJ (Nona Scientific) But if you want to, when you say... 10:00 - Andrew Hartmann (UTAK Laboratories) Send me your drug list. Why don't you do two things? So send me the list of all of the drugs, tell me what concentration you would want if we're making it in oral fluid, and tell me what concentration you would want if we're making it in a methanol, where you're then, you know, squirting the methanol into the oral fluid. And I'll quote you both options so we can see how it prices out, and then we can kind of decide, you know, what's going to be the best fit for you. Okay, okay, good. 10:28 - CJ (Nona Scientific) Does that sound like a good plan? 10:31 - Andrew Hartmann (UTAK Laboratories) Yeah. 10:33 - CJ (Nona Scientific) Yes. Perfect. 10:36 - Andrew Hartmann (UTAK Laboratories) So, any questions for us on how this process works, or anything you want to review while you have me? 10:46 - CJ (Nona Scientific) Oh, after the quote is accepted, after the order, if I have a fixed order, how long can you stand out the sample? 10:55 - Andrew Hartmann (UTAK Laboratories) The quote will confirm that, but it's usually around 15 to 20 business. a fixed order, if if If it's an urgent need or something, let us know and we can try to expedite, but our normal lead time is going to be about three to four weeks. Oh, we did need it too, yeah. 11:16 - CJ (Nona Scientific) Okay, I'll send you this. Perfect. 11:19 - Andrew Hartmann (UTAK Laboratories) Yeah, once I get it, I'll reply back letting you know I have it and I've submitted the request and then I'll connect with you in a couple of days once I have the quotes and we'll go over those. Okay, okay. Thank you, Andrew. Thank you. I really appreciate your time. Bye. Bye. Bye.